作者: Gary L. Simon
DOI: 10.1001/ARCHINTE.1984.00350130040007
关键词: Clinical significance 、 Surgery 、 Endocarditis 、 Heart disease 、 Bacteremia 、 Antibiotics 、 Medicine 、 valvular heart disease 、 Intensive care medicine 、 Chemotherapy 、 Endocarditis prophylaxis
摘要: Transient bacteremia is usually asymptomatic and thus of little clinical significance in most patients. Individuals with valvular heart disease are a notable exception, because circulating bacteria may lodge on damaged or prosthetic valves, resulting bacterial endocarditis. can occur many medical procedures, the use antibiotics to prevent endocarditis high-risk patient has become an accepted practice. This based premise that microbial seeding valve be prevented by prior administration antibiotics. 1-3 There no direct evidence for efficacy this approach man; therefore, recommendations must studies using animal models. 1,4 The issue never completely resolved, controlled human study not feasible. Based calculated risk 0.2%, Durack 5 estimated at least 6,000 patients who have undergoing dental procedures