Detection of new quantitative trait Loci for susceptibility to transmissible spongiform encephalopathies in mice.
作者： Isabelle Lantier , Pierre Sarradin , Frédéric Lantier , Carole R Moreno , Jean-Michel Elsen
DOI: 10.1093/GENETICS/165.4.2085
关键词: Quantitative trait locus 、 Genotype 、 Genetic linkage 、 Virology 、 Scrapie 、 Genetics 、 Allele 、 Genome 、 PRNP 、 Strain (biology) 、 Biology
摘要: Susceptibility to scrapie is largely controlled by the PRNP gene in mice and several other species. However, individuals with identical susceptibility Prnp alleles may have very different incubation periods, suggesting influence of environmental genetic factors. To detect loci influencing TSE, two mouse lines carrying same genotype (C57BL RIII) were crossed produce an F2 population inoculated intracerebrally a mouse-adapted strain. Linkage was studied between 72 markers age death animals. Six QTL detected, at genome-wide significant level (chromosomes 5 7) four suggestive 4, 6, 8, 17). Our results confirmed existence some that detected previously 7, 8) while others found only present study Furthermore, it seems 4 are involved resistance as well BSE.
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