Cholesterol Overload: Contact Sites to the Rescue!
作者： Carlos Enrich , Carles Rentero , Thomas Grewal , Clare E. Futter , Emily R. Eden
关键词: Phenotype 、 Chemistry 、 Endoplasmic reticulum 、 Cell biology 、 Mutant 、 Endocytic cycle 、 Cholesterol 、 Organelle 、 Endosome 、 NPC1
摘要: Delivery of low-density lipoprotein-derived cholesterol to the endoplasmic reticulum (ER) is essential for homeostasis, yet mechanism this transport has largely remained elusive. Two recent reports shed some light on process, uncovering a role Niemann Pick type-C1 protein (NPC1) in formation membrane contact sites (MCS) between late endosomes (LE)/lysosomes (Lys) and ER. Both studies identified loss MCS cells lacking functional NPC1, where accumulates endocytic organelles. Remarkably, taking different approaches, both have made striking observation that expansion LE/Lys-ER can rescue accumulation phenotype NPC1 mutant or deficient cells. In cases, was shown be transported ER, demonstrating importance ER-LE/Lys direct
sagepub.com
sci-hub.se 参考文章(15)
Camilla Raiborg, Eva M Wenzel, Harald Stenmark, ER–endosome contact sites: molecular compositions and functions The EMBO Journal. ,vol. 34, pp. 1848- 1858 ,(2015) , 10.15252/EMBJ.201591481
David L. Marks, Michel Dominguez, Keishi Narita, Richard E. Pagano, Amit Choudhury, Christine L. Wheatley, Vishwajeet Puri, Deepak K. Sharma, Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells Journal of Clinical Investigation. ,vol. 109, pp. 1541- 1550 ,(2002) , 10.1172/JCI15420
Mark Charman, Barry E. Kennedy, Nolan Osborne, Barbara Karten, MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein Journal of Lipid Research. ,vol. 51, pp. 1023- 1034 ,(2010) , 10.1194/JLR.M002345
Emily R. Eden, Elena Sanchez-Heras, Anna Tsapara, Andrzej Sobota, Tim P. Levine, Clare E. Futter, Annexin A1 Tethers Membrane Contact Sites that Mediate ER to Endosome Cholesterol Transport Developmental Cell. ,vol. 37, pp. 473- 483 ,(2016) , 10.1016/J.DEVCEL.2016.05.005
Léa P Wilhelm, Corinne Wendling, Benoît Védie, Toshihide Kobayashi, Marie‐Pierre Chenard, Catherine Tomasetto, Guillaume Drin, Fabien Alpy, STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites. The EMBO Journal. ,vol. 36, pp. 1412- 1433 ,(2017) , 10.15252/EMBJ.201695917
Kexin Zhao, Neale D. Ridgway, Oxysterol-Binding Protein-Related Protein 1L Regulates Cholesterol Egress from the Endo-Lysosomal System Cell Reports. ,vol. 19, pp. 1807- 1818 ,(2017) , 10.1016/J.CELREP.2017.05.028
Yvette C. Wong, Daniel Ysselstein, Dimitri Krainc, Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis Nature. ,vol. 554, pp. 382- 386 ,(2018) , 10.1038/NATURE25486
Neale D. Ridgway, Kexin Zhao, Cholesterol transfer at endosomal-organelle membrane contact sites. Current Opinion in Lipidology. ,vol. 29, pp. 212- 217 ,(2018) , 10.1097/MOL.0000000000000506
Birol Cabukusta, Jacques Neefjes, Mechanisms of lysosomal positioning and movement. Traffic. ,vol. 19, pp. 761- 769 ,(2018) , 10.1111/TRA.12587
Jaspreet Sandhu, Shiqian Li, Louise Fairall, Simon G. Pfisterer, Jennifer E. Gurnett, Xu Xiao, Thomas A. Weston, Dipti Vashi, Alessandra Ferrari, Jose L. Orozco, Celine L. Hartman, David Strugatsky, Stephen D. Lee, Cuiwen He, Cynthia Hong, Haibo Jiang, Laurent A. Bentolila, Alberto T. Gatta, Tim P. Levine, Annie Ferng, Richard Lee, David A. Ford, Stephen G. Young, Elina Ikonen, John W.R. Schwabe, Peter Tontonoz, Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells. Cell. ,vol. 175, pp. 514- 529 ,(2018) , 10.1016/J.CELL.2018.08.033