STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites.
作者： Léa P Wilhelm , Corinne Wendling , Benoît Védie , Toshihide Kobayashi , Marie‐Pierre Chenard
关键词:
摘要: Abstract StAR‐related lipid transfer domain‐3 (STARD3) is a sterol‐binding protein that creates endoplasmic reticulum (ER)–endosome contact sites. How this protein, at the crossroad between sterol uptake and synthesis pathways, impacts intracellular distribution of was ill‐defined. Here, by using in situ cholesterol labeling quantification, we demonstrated STARD3 induces accumulation in endosomes expense plasma membrane. STARD3‐mediated routing depends both on its activity ability to create ER–endosome contacts. Corroborating this, in vitro reconstitution assays indicated ER‐anchored partner, Vesicle‐associated membrane protein‐associated (VAP), assemble into machine allows highly efficient transport within Thus, transporter scaffolding contacts modulating cellular repartition delivering endosomes.
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