Range versus density dependence of proton-therapy beams in human tissues

作者: Márius Pavlovič , Milan Pavúk , Andreas Hammerle , Vladimír Nečas

DOI: 10.1016/J.NIMB.2018.08.011

关键词: Function (mathematics)Computational physicsProton therapyRange (statistics)Monte Carlo methodStopping power (particle radiation)Density dependencePhysics

摘要: Abstract Range versus density dependence of proton-therapy beams in human tissues is discussed the paper. The main attention paid to energy-scaling simple fitting functions that fit range-to-density for single proton-beam energies. These have been found by ranges obtained with aid Monte Carlo module SRIM2013. simulations run 28 at 8 energies from 60 MeV 220 MeV. It has shown a function depends solely on target can be each energy. After energy-scaling, fitted compared ranges. We conclude final energy-scaled provides within 0.4% range (on average), which less than 30% natural range-straggling (1.4% average). worst data-point an off-set 1.7% range.

参考文章(18)
Gerhard Kraft, Michael KrÄMer, Linear Energy Transfer and Track Structure Advances in radiation biology. ,vol. 17, pp. 1- 52 ,(1993) , 10.1016/B978-0-12-035417-7.50004-0
Hywel Owen, Antony Lomax, Simon Jolly, Current and future accelerator technologies for charged particle therapy Nuclear Instruments & Methods in Physics Research Section A-accelerators Spectrometers Detectors and Associated Equipment. ,vol. 809, pp. 96- 104 ,(2016) , 10.1016/J.NIMA.2015.08.038
James F Ziegler, Matthias D Ziegler, Jochen P Biersack, SRIM : the stopping and range of ions in matter Published in <b>2008</b> in Chester Md) by SRIM. ,(2008)
James F. Ziegler, M.D. Ziegler, J.P. Biersack, SRIM – The stopping and range of ions in matter (2010) Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms. ,vol. 268, pp. 1818- 1823 ,(2010) , 10.1016/J.NIMB.2010.02.091
I. Strašík, V. Chetvertkova, E. Mustafin, M. Pavlovič, A. Belousov, Depth profiling of residual activity ofU237fragments as a range verification technique forU238primary ion beam Physical Review Special Topics-accelerators and Beams. ,vol. 15, pp. 071001- ,(2012) , 10.1103/PHYSREVSTAB.15.071001
Johanna Kempe, Anders Brahme, Energy-range relation and mean energy variation in therapeutic particle beams Medical Physics. ,vol. 35, pp. 159- 170 ,(2007) , 10.1118/1.2815935
Thomas Bortfeld, An analytical approximation of the Bragg curve for therapeutic proton beams Medical Physics. ,vol. 24, pp. 2024- 2033 ,(1997) , 10.1118/1.598116