5-Hydroxy-2-pyrazolines and Some of Their 1-Substituted Analogs
作者： K. N. Zelenin , A. R. Tugusheva , S. I. Yakimovich , V. V. Alekseev , E. V. Zerova
关键词: Medicinal chemistry 、 Chemistry 、 Hydrazine 、 Tautomer
摘要: The use of 1,3-dicarbonyl compounds containing strong electron-withdrawing substituents (perfluoroalkyl, 4-nitrophenyl) at one the carbonyl groups in reaction with hydrazine or its monosubstituted derivatives (4-nitro- and 2,4-dinitrophenylhydrazines) leads to formation stable intermediates for synthesis pyrazoles (5-hydroxy-2-pyrazolines) their linear tautomers (hydrazones).
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sci-hub.se 参考文章(6)
Tarozaemon Nishiwaki, Studies on Heterocyclic Chemistry. IV. Preparation of Several Trifluoromethyl-substituted Heterocyclic Compounds and Observation of Metastable Ion in the Mass Spectra of Trifluoromethyl-pyrazoles Bulletin of the Chemical Society of Japan. ,vol. 42, pp. 3024- 3026 ,(1969) , 10.1246/BCSJ.42.3024
MR Grimmett, KHR Lim, RT Weavers, The N-Alkylation and N-Arylation of Unsymmetrical Pyrazoles Australian Journal of Chemistry. ,vol. 32, pp. 2203- 2213 ,(1979) , 10.1071/CH9792203
P. Yates, D.G. Farnum, D.W. Wiley, Aliphatic diazo compounds—VII Tetrahedron. ,vol. 18, pp. 881- 891 ,(1962) , 10.1016/S0040-4020(01)92741-3
D. M. BURNESS, -Keto Acetals. I. Synthesis of Pyrazoles and Pyrimidines and the Steric Inhibition of Resonance in 5-Alkyl-1-p-nitrophenylpyrazoles Journal of Organic Chemistry. ,vol. 21, pp. 97- 101 ,(1956) , 10.1021/JO01107A020
Алексеев В В, Зерова И В, Кузнецова О Б, Якимович С И, Саминская А Г, Зеленин К Н, Карбоногидразоны и их кольчато‐цепная таутомерия. Zhurnal Organicheskoi Khimii. ,vol. 35, pp. 383- 389 ,(1999)
Kirill N. Zelenin, Valery V. Alekseyev, Alja R. Tygysheva, Stanislav I. Yakimovitch, 5-hydroxy-4,5-dihydropyrazoles Tetrahedron. ,vol. 51, pp. 11251- 11256 ,(1995) , 10.1016/0040-4020(95)00672-U