The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis

摘要: Metastasis is a critical event affecting breast cancer patient survival. To identify molecules contributing to the metastatic process, we analysed The Cancer Genome Atlas (TCGA) data and identified 41 genes whose expression inversely correlated with Here show that GABAA receptor alpha3 (Gabra3), normally exclusively expressed in adult brain, also cancer, high of Gabra3 being We demonstrate activates AKT pathway promote cell migration, invasion metastasis. Importantly, find an A-to-I RNA-edited form only non-invasive cancers edited suppresses A-to-I-edited has reduced surface activation required for migration invasion. Our study demonstrates significant role mRNA-edited