Editing of Neurotransmitter Receptor and Ion Channel RNAs in the Nervous System

摘要: The central dogma of molecular biology defines the major route for transfer genetic information from genomic DNA to messenger RNA three-dimensional proteins that affect structure and function. Like alternative splicing, post-transcriptional conversion adenosine inosine (A-to-I) by editing can dramatically expand diversity transcriptome generate multiple, functionally distinct protein isoforms a single locus. While has been identified in virtually all tissues, such modifications have best characterized RNAs encoding both ligand- voltage-gated ion channels neurotransmitter receptors. These processing events shown play an important role function encoded products and, several cases, be critical normal development nervous system.