Highly sensitive detection using microring resonator and nanopores

摘要: One of the most significant challenges facing physical and biological scientists is accurate detection identification single molecules in free-solution environments. The ability to perform such sensitive selective measurements opens new avenues for a large number applications biological, medical chemical analysis, where small sample volumes low analyte concentrations are norm. Access information at or few scale rendered possible by fine combination recent advances technologies. We propose novel method that combines highly label-free resonant sensing obtained with high-Q microcavities position control nanoscale pores (nanopores). In addition be sensitive, our technique immobilization free does not rely on surface biochemistry bind probes chip. This advantage, both term biology uncertainties fewer preparation steps. Through photonic structures translocation through nanopore end pipette, solid-state membrane, we believe can achieved field biosensing. Silicon microrings advantageous sensitivity, multiplexing, microfabrication chosen this study. nanopores, consider nanopipette, pore being approach from pipette nanoprecise mechanical control. Alternatively, solid state nanopores fabricated supporting ring. Both configuration discussed paper, implementation sensitivity.