Molecular Conformation of GABA

摘要: CURTIS et al.1,2 have described evidence suggesting that the alkaloid bicuculline is a specific antagonist to action of γ-aminobutyric acid (GABA), possible inhibitory transmitter in mammalian brain3,4. By considering structural models, they suggested3 as stereochemical basis for this antagonism geometrical configuration which N and Ol=C1—O2 GABA isosteric with C2—Cl—Ol (Fig. 1a b). An alternative GABA, would give greater degree similarity bicuculline, depicted Fig. 1c. In both molecules now seen be isosterically related Ol=Cl—O2 located at an angle about 40° plane O=Cl—O group viewed towards C2 2). contrast Curtis's suggestion, there not only congruence but also identical matching atomic species.