Eye-drop vaccine containing copolymer 1 for therapeutic immunization
作者： Valentin Fulga , Michal Eisenbach-Schwartz , Sharon Bakalash
DOI:
关键词: Immunology 、 Disease 、 Peripheral nervous system 、 Eye drop 、 Toxicity 、 Central nervous system 、 Biology 、 Regeneration (biology) 、 Glutamate receptor 、 Immunization
摘要: The invention provides an eye-drop vaccine for therapeutic immunization of a mammal comprising Copolymer 1, 1-related peptide, or polypeptide, treating neuronal degeneration caused by injury disease, disorder condition in the central nervous system (CNS) peripheral (PNS), preventing inhibiting secondary which may otherwise follow primary CNS, promoting nerve regeneration CNS PNS after injury, protecting and cells from glutamate toxicity.
lens.org 参考文章(16)
Ehud Hauben, Ester Yoles, Michal Eisenbach-Schwartz, Use of poly-glu, tyr for neuroprotective therapy ,(2002)
Jonathan Kipnis, Michal Eisenbach-Schwartz, Method and vaccine comprising copolymer 1 for treatment of psychiatric disorders ,(2004)
Ruth Arnon, Milka Linenberg, Michael Sela, Adrian Gilbert, Dvora Teitelbaum, Rivka Riven-Kreitman, Treatment of multiple sclerosis through ingestion or inhalation of copolymer-1 ,(1998)
Phillip Scott, Giorgio Trinchieri, Compositions and methods for use of IL-12 as an adjuvant ,(1994)
Ruth Maron, Howard L. Weiner, Anthony Slavin, TREATMENT OF MULTIPLE SCLEROSIS USING COP-1 AND Th2-ENHANCING CYTOKINES ,(1999)
D. Teitelbaum, R. Arnon, M. Sela, Immunomodulation of experimental autoimmune encephalomyelitis by oral administration of copolymer 1. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 3842- 3847 ,(1999) , 10.1073/PNAS.96.7.3842
J. Kipnis, E. Yoles, Z. Porat, A. Cohen, F. Mor, M. Sela, I. R. Cohen, M. Schwartz, T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: Possible therapy for optic neuropathies Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 7446- 7451 ,(2000) , 10.1073/PNAS.97.13.7446
Eti Yoles, Jonathan Kipnis, Michael Sela, Michal Eisenbach-Schwartz, Irun R. Cohen, The use of copolymer 1 and related peptides and polypeptides and t cells treated therewith for neuroprotective therapy ,(2001)
H. Schori, J. Kipnis, E. Yoles, E. WoldeMussie, G. Ruiz, L. A. Wheeler, M. Schwartz, Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: Implications for glaucoma Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 3398- 3403 ,(2001) , 10.1073/PNAS.041609498
J Klein, D Vidović, Z A Nagy, Recessive T cell response to poly (Glu50Tyr50) possibly caused by self tolerance. Journal of Immunology. ,vol. 134, pp. 3563- 3568 ,(1985)