Oxidative damage in liver after perinatal intoxication with lead and/or cadmium
作者： Elvira Luján Massó , Laura Corredor , Maria Teresa Antonio
DOI: 10.1016/J.JTEMB.2007.03.002
关键词: TBARS 、 Oxidative stress 、 Lead acetate 、 Internal medicine 、 Biochemistry 、 Cadmium 、 Cadmium poisoning 、 Alkaline phosphatase 、 Toxicity 、 Endocrinology 、 Chemistry 、 Catalase
摘要: Lead acetate (300 mg Pb/L) and/or cadmium (10mg Cd/L) in blood and liver were administrated as drinking water to pregnant Wistar rats from day 1 of pregnancy parturition (day 0) or until weaning 21), investigate the toxic effects liver. Both metals produced mycrocitic anaemia pups well oxidative damage liver, suggested by significant increase TBARS production high catalase activity. Moreover, intense alkaline acid phosphatase activity, used biomarkers adaptation damaging factors, was observed. In addition, toxikinetics are different for Pb Cd: while Cd is a hepatotoxic 0, not 21. Finally, simultaneous perinatal administration both seems protect, at least, against toxicity separately.
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