Protective effects of vitamin E against lead-induced deterioration of membrane associated type-I iodothyronine 5'-monodeiodinase (5'D-I) activity in male mice

摘要: Abstract The protective role of vitamin E (vit E) on lead-induced thyroid dysfunction with special reference to type-I iodothyronine 5′-monodeiodinase (5′D-I) activity in mice liver was investigated. Daily intraperitoneal (i.p.) injection lead acetate (0.5 mg/kg body weight) for 30 days significantly decreased serum 3,3′,5-triiodothyronine (T 3 ) concentration and hepatic 5′D-I activity. Furthermore, increased peroxidative reactions involving membrane components (lipid peroxidation, LPO) while the activities antioxidant enzymes such as superoxide dismutase (SOD) catalase (CAT) were mouse liver. Simultaneous administration vit (5 0.5 weight restored function by maintaining normal hormone concentrations. It also prevented increase LPO inhibition SOD CAT We suggest that intact structure is a must may prevent induced architecture.