Activity of superoxide dismutase and catalase in people protractedly exposed to lead compounds.
作者： Sławomir Kasperczyk , Jolanta Zalejska-Fiolka , Aleksandra Kasperczyk , Ewa Birkner
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摘要: Lead can modify pro/antioxidant status by influencing antioxidant enzymes. As the results of experimental researches are divergent, purpose this research was to evaluate activity enzymes that play a vital role in defence against ROS blood people protractedly exposed lead compounds. The study population included 172 healthy employees zinc and steelworks. Workers (L) were divided into 2 groups: first workers with mean concentration (PbB) from 25-35 microl/dl (LL group), second group high exposure (HL group)--with PbB over 35 microl/dl. administration control group. There no significant changes catalase mitochondrial SOD population. ZnCu-SOD significantly increased, both plasma erythrocytes, but LL subgroup about 42% (p=0.044), then erythrocytes HL 23% (p=0.012) when compared Concentration TBARS-MDA increased serum erythrocytes. In (mean 15 +/- 10 years), there is observed an blood, which seems be adoptive mechanism raised amount production reactive oxygen species (ROS) caused lead.
参考文章(37)
Hugo Aebi, Catalase in vitro Methods in Enzymology. ,vol. 105, pp. 121- 126 ,(1984) , 10.1016/S0076-6879(84)05016-3
Wasowicz W, Gromadzińska J, Rydzyński K, Blood concentration of essential trace elements and heavy metals in workers exposed to lead and cadmium. International Journal of Occupational Medicine and Environmental Health. ,vol. 14, pp. 223- ,(2001)
Mohammed A. El-Missiry, Prophylactic effect of melatonin on lead-induced inhibition of heme biosynthesis and deterioration of antioxidant systems in male rats. Journal of Biochemical and Molecular Toxicology. ,vol. 14, pp. 57- 62 ,(2000) , 10.1002/(SICI)1099-0461(2000)14:1<57::AID-JBT8>3.0.CO;2-B
Stephen C. Bondy, S.X. Guo, Lead potentiates iron-induced formation of reactive oxygen species Toxicology Letters. ,vol. 87, pp. 109- 112 ,(1996) , 10.1016/0378-4274(96)03766-6
Abdelrahim A Hunaiti, M Soud, Effect of lead concentration on the level of glutathione, glutathione S-transferase, reductase and peroxidase in human blood Science of The Total Environment. ,vol. 248, pp. 45- 50 ,(2000) , 10.1016/S0048-9697(99)00548-3
J ONUKI, M MEDEIROS, E BECHARA, P MASCIO, 5-Aminolevulinic acid induces single-strand breaks in plasmid pBR322 DNA in the presence of Fe2+ ions Biochimica et Biophysica Acta. ,vol. 1225, pp. 259- 263 ,(1994) , 10.1016/0925-4439(94)90004-3
Hiroshi Ohkawa, Nobuko Ohishi, Kunio Yagi, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Analytical Biochemistry. ,vol. 95, pp. 351- 358 ,(1979) , 10.1016/0003-2697(79)90738-3
Stefan R. Ribarov, Ludmil C. Benov, Ilia C. Benchev, The effect of lead on hemoglobin-catalyzed lipid peroxidation Biochimica et Biophysica Acta. ,vol. 664, pp. 453- 459 ,(1981) , 10.1016/0005-2760(81)90123-5
Shyam Sunder Chaurasia, Anand Kar, Protective effects of vitamin E against lead-induced deterioration of membrane associated type-I iodothyronine 5'-monodeiodinase (5'D-I) activity in male mice Toxicology. ,vol. 124, pp. 203- 209 ,(1997) , 10.1016/S0300-483X(97)00155-8
Augusta A. Mylroie, Henry Collins, Constance Umbles, Joseph Kyle, Erythrocyte superoxide dismutase activity and other parameters of copper status in rats ingesting lead acetate Toxicology and Applied Pharmacology. ,vol. 82, pp. 512- 520 ,(1986) , 10.1016/0041-008X(86)90286-3