Immunophenotypic patterns of childhood acute leukemias in Indonesia.

摘要: Background: Immunophenotyping, as suggested by WHO, may improve diagnosis of childhood leukemia since it offers a better classification the hematopoietic lineage malignant cells compared to morphology. Therefore, we aimed determine proportion immunophenotypic subtypes acute in Indonesian children. Methods. Samples were obtained from patients (0-14 years age) 4 hospitals Indonesia. We analyzed 541 suspected samples presented over 4-year period (March 2006 - July 2010) flow cytometry. Immunophenotyping allowed into myeloid (AML) and ALL (B-lineage T-lineage ALL). Results. Of samples, 136 tested using single color method 405 with three-color method. Concordance morphology was very good (κ=0.82) panel 15 monoclonal antibodies (n=387). A relatively high percentage classified AML (23%). 83% B-lineage 17% T- ALL. Nine out 239 morphological labeled AML, 12/79 fact Conclusion. multi-center study proved feasible appears particularly important for prognostic assessment low income countries such