The use of mesenchymal (skeletal) stem cells for treatment of degenerative diseases: Current status and future perspectives

作者: Basem M. Abdallah , Moustapha Kassem

DOI: 10.1002/JCP.21572

关键词: Clinical uses of mesenchymal stem cellsMesenchymal stem cellCancer researchMedicineBone marrowAdult stem cellEndothelial stem cellStem cellImmunologyStem cell transplantation for articular cartilage repairMultipotent Stem Cell

摘要: Human bone marrow derived-mesenchymal (skeletal) stem (MSC) cells are a group of non-hematopoietic residing in the perivascular niches marrow. These have capacity to differentiate mainly into mesoderm-type such as osteoblasts, chondrocytes and adipocytes possibly but not proven non-mesodermal cell types. Recently, there has been an increased interest understanding biology MSC due their potential use cell-based therapy for multiple degenerative diseases. Here, we will provide update on current status these novel therapeutic opportunities. J. Cell. Physiol. 218: 9-12, 2009. (c) 2008 Wiley-Liss, Inc.

参考文章(83)
Michael R. Bishop, Robert M. Dean, Graft-versus-host disease: emerging concepts in prevention and therapy. Current hematology reports. ,vol. 2, pp. 287- 294 ,(2003)
Reed E. Pyeritz, Malcolm K. Brenner, Edwin M. Horwitz, Darwin J. Prockop, Lorraine A. Fitzpatrick, Winston W. K. Koo, Patricia L. Gordon, Michael Neel, Michael Sussman, Paul Orchard, Jeffrey C. Marx, Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta Nature Medicine. ,vol. 5, pp. 309- 313 ,(1999) , 10.1038/6529
Wenrong Xu, Xiran Zhang, Hui Qian, Wei Zhu, Xiaochun Sun, Jiabo Hu, Hong Zhou, Yongchang Chen, Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro. Experimental Biology and Medicine. ,vol. 229, pp. 623- 631 ,(2004) , 10.1177/153537020422900706
Omer N. Koç, Stanton L. Gerson, Brenda W. Cooper, Stephanie M. Dyhouse, Stephen E. Haynesworth, Arnold I. Caplan, Hillard M. Lazarus, Rapid Hematopoietic Recovery After Coinfusion of Autologous-Blood Stem Cells and Culture-Expanded Marrow Mesenchymal Stem Cells in Advanced Breast Cancer Patients Receiving High-Dose Chemotherapy Journal of Clinical Oncology. ,vol. 18, pp. 307- 316 ,(2000) , 10.1200/JCO.2000.18.2.307
Edwin M. Horwitz, Darwin J. Prockop, Patricia L. Gordon, Winston W. K. Koo, Lorraine A. Fitzpatrick, Michael D. Neel, M. Elizabeth McCarville, Paul J. Orchard, Reed E. Pyeritz, Malcolm K. Brenner, Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta Blood. ,vol. 97, pp. 1227- 1231 ,(2001) , 10.1182/BLOOD.V97.5.1227
Stan Gronthos, Andrew CW Zannettino, Shelley J Hay, Songtao Shi, Stephen E Graves, Angela Kortesidis, Paul J Simmons, Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow. Journal of Cell Science. ,vol. 116, pp. 1827- 1835 ,(2003) , 10.1242/JCS.00369
Y. Miura, M. Miura, S. Gronthos, M. R. Allen, C. Cao, T. E. Uveges, Y. Bi, D. Ehirchiou, A. Kortesidis, S. Shi, L. Zhang, Defective osteogenesis of the stromal stem cells predisposes CD18-null mice to osteoporosis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 14022- 14027 ,(2005) , 10.1073/PNAS.0409397102
Hajime Ohgushi, Noriko Kotobuki, Hiroyuki Funaoka, Hiroko Machida, Motohiro Hirose, Yasuhito Tanaka, Yoshinori Takakura, Tissue engineered ceramic artificial joint—ex vivo osteogenic differentiation of patient mesenchymal cells on total ankle joints for treatment of osteoarthritis Biomaterials. ,vol. 26, pp. 4654- 4661 ,(2005) , 10.1016/J.BIOMATERIALS.2004.11.055
Irina Kratchmarova, Blagoy Blagoev, Mandana Haack-Sorensen, Moustapha Kassem, Matthias Mann, None, Mechanism of Divergent Growth Factor Effects in Mesenchymal Stem Cell Differentiation Science. ,vol. 308, pp. 1472- 1477 ,(2005) , 10.1126/SCIENCE.1107627
Lynne M. Ball, Maria Ester Bernardo, Helene Roelofs, Arjan Lankester, Angela Cometa, R. Maarten Egeler, Franco Locatelli, Willem E. Fibbe, Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation. Blood. ,vol. 110, pp. 2764- 2767 ,(2007) , 10.1182/BLOOD-2007-04-087056