Mechanism of Divergent Growth Factor Effects in Mesenchymal Stem Cell Differentiation

作者: Irina Kratchmarova , Blagoy Blagoev , Mandana Haack-Sorensen , Moustapha Kassem , Matthias Mann

DOI: 10.1126/SCIENCE.1107627

关键词:

摘要: … To discover critical differences in the signaling mechanisms of EGF and PDGF that led to the differential effects on osteoblast differentiation of hMSC, we sought to identify and directly …

参考文章(31)
Nandini Ghosh-Choudhury, Sherry L. Abboud, Riko Nishimura, Anthony Celeste, Lenin Mahimainathan, Goutam Ghosh Choudhury, Requirement of BMP-2-induced Phosphatidylinositol 3-Kinase and Akt Serine/Threonine Kinase in Osteoblast Differentiation and Smad-dependent BMP-2 Gene Transcription Journal of Biological Chemistry. ,vol. 277, pp. 33361- 33368 ,(2002) , 10.1074/JBC.M205053200
Rama K. Jaiswal, Neelam Jaiswal, Scott P. Bruder, Gabriel Mbalaviele, Daniel R. Marshak, Mark F. Pittenger, Adult Human Mesenchymal Stem Cell Differentiation to the Osteogenic or Adipogenic Lineage Is Regulated by Mitogen-activated Protein Kinase Journal of Biological Chemistry. ,vol. 275, pp. 9645- 9652 ,(2000) , 10.1074/JBC.275.13.9645
H. Qi, D. J. Aguiar, S. M. Williams, A. La Pean, W. Pan, C. M. Verfaillie, Identification of genes responsible for osteoblast differentiation from human mesodermal progenitor cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 3305- 3310 ,(2003) , 10.1073/PNAS.0532693100
Margaret F Favata, Kurumi Y Horiuchi, Elizabeth J Manos, Andrea J Daulerio, Deborah A Stradley, Wendi S Feeser, Drew E Van Dyk, William J Pitts, Richard A Earl, Frank Hobbs, Robert A Copeland, Ronald L Magolda, Peggy A Scherle, James M Trzaskos, None, IDENTIFICATION OF A NOVEL INHIBITOR OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE Journal of Biological Chemistry. ,vol. 273, pp. 18623- 18632 ,(1998) , 10.1074/JBC.273.29.18623
Rebecca B. Riggins, Lawrence A. Quilliam, Amy H. Bouton, Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3. Journal of Biological Chemistry. ,vol. 278, pp. 28264- 28273 ,(2003) , 10.1074/JBC.M303535200
Francesc Viñals, Teresa López-Rovira, Jose Luis Rosa, Francesc Ventura, Inhibition of PI3K/p70 S6K and p38 MAPK cascades increases osteoblastic differentiation induced by BMP-2 FEBS Letters. ,vol. 510, pp. 99- 104 ,(2002) , 10.1016/S0014-5793(01)03236-7
Jeffrey A. Ranish, Eugene C. Yi, Deena M. Leslie, Samuel O. Purvine, David R. Goodlett, Jimmy Eng, Ruedi Aebersold, The study of macromolecular complexes by quantitative proteomics. Nature Genetics. ,vol. 33, pp. 349- 355 ,(2003) , 10.1038/NG1101
Kenneth W. Liechty, Tippi C. MacKenzie, Aimen F. Shaaban, Antoneta Radu, AnneMarie B. Moseley, Robert Deans, Daniel R. Marshak, Alan W. Flake, Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep Nature Medicine. ,vol. 6, pp. 1282- 1286 ,(2000) , 10.1038/81395
Shao-En Ong, Blagoy Blagoev, Irina Kratchmarova, Dan Bach Kristensen, Hanno Steen, Akhilesh Pandey, Matthias Mann, None, Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Molecular & Cellular Proteomics. ,vol. 1, pp. 376- 386 ,(2002) , 10.1074/MCP.M200025-MCP200
Tony Pawson, Piers Nash, Assembly of cell regulatory systems through protein interaction domains. Science. ,vol. 300, pp. 445- 452 ,(2003) , 10.1126/SCIENCE.1083653