Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia.

摘要: Pathomorphology of the limbic system has been described in post-mortem studies schizophrenia. To determine whether this could be detected living patients and was not secondary to treatment or chronicity disease itself, we measured volumes hippocampus-amygdala complex adjoining temporal horns 34 their first episode schizophrenia 25 normal volunteers using T1 weighted contiguous coronal magnetic resonance images 3.1 mm width. The results demonstrate abnormal medial lobe morphology a subgroup at onset illness. There were clear laterality effects sex differences: hippocampal tissue significantly smaller only left hemisphere male patients, whereas enlargement whole horn its anterior portion present on side both sexes. Dysfunction mesiotemporal structures might explain some clinical features disease.