Synthesis and crystal structures of cobalt(II), cadmium(II), and zinc(II) complexes of 4-nitro phenylcyanamide: enhancing the biological properties through bound to human serum albumin
作者： Mehdi Jazestani , Hossein Chiniforoshan , Leila Tabrizi , Patrick McArdle
DOI: 10.1080/07391102.2016.1201006
关键词: Crystal structure 、 Stereochemistry 、 Zinc 、 Metal 、 Plasma protein binding 、 Nitro 、 Chemistry 、 Circular dichroism 、 Nuclear chemistry 、 Human serum albumin 、 Cobalt
摘要: Metal complexes of the type [Co(phen)2(4-NO2pcyd)2].CH3OH, 1, [Zn(phen)2(4-NO2pcyd)2].CH3OH, 2, [Cd(phen)2(4-NO2pcyd)2], and 3, (phen = 1,10-phenanthroline, 4-NO2pcyd = 4-nitro phenylcyanamide) have been studied. The synthesis, characterization, biological activities 1-3 investigated. geometries were confirmed by single-crystal X-ray crystallography. interactions with human serum albumin (HSA) studied using fluorescence circular dichroism spectroscopy. thermodynamic studies showed reaction for binding HSA is hydrophobic (ΔH0 ˂ 0 ΔS0 > 0). in vitro cytotoxic potential their examined. enhance about 3-fold cytotoxicity cancer cells lines.
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