Comparison of neuroendocrine tumor detection and characterization using DOTATOC-PET in correlation with contrast enhanced CT and delayed contrast enhanced MRI
作者： F.L. Giesel , C. Kratochwil , A. Mehndiratta , S. Wulfert , J.H. Moltz
DOI: 10.1016/J.EJRAD.2011.11.007
关键词: Positron emission tomography 、 Lesion 、 Magnetic resonance imaging 、 Medicine 、 Radiology 、 Somatostatin receptor 、 Octreotide 、 PET-CT 、 Nuclear medicine 、 Metastasis 、 Neuroendocrine tumors
摘要: Abstract Purpose We evaluated the rate of successful characterization gastroenteropancreatic neuroendocrine tumors (NETs) present with an increased somatostatin receptor, comparing CE-CT CE-MRI, each in correlation DOTATOC-PET. Methods and materials 8 patients GEP-NET were imaged using CE-MRI (Gd-EOB-DTPA), (Imeron 400) Contrast-enhancement normal liver-tissue metastasis was quantified ROI-technique. Tumor delineation assessed visual-score blind-read-analysis by two experienced radiologists. Results Out 40 liver metastases NETs, all detected lesion extent could be adequately assessed, whereas CT failed to detect 20% metastases. The blind-read-score arterial portal phase median −0.65 −1.4, respectively, 2.7 for delayed-MRI. quantitative ROI-analysis presented improved contrast-enhancement-ratio a 1.2, 1.6 3.3 arterial, portal-phase delayed-MRI respectively. Conclusion Late superior providing additionally morphologic exact extension hepatic from tumor Therefore, late enhanced Gd-EOB-DTPA-MRI seems adequate imaging modality combination DOTATOC-PET provide complementary (macroscopic molecular) metastasized NETs.
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