Early-Life Social Isolation Influences Mouse Ultrasonic Vocalizations during Male-Male Social Encounters

摘要: Early-life social isolation has profound effects on adult competence. This is often expressed as increased aggression or inappropriate displays of courtship-related behaviors. The incompetence exhibited by isolated animals could be in part due to an altered ability participate communicatory exchanges. House mice (Mus musculus) present excellent model for exploring this idea, because a well-established influence their behavior, and engage communication via multiple sensory modalities. Here, we tested the prediction that during early life would ultrasonic vocalizations (USVs) emitted male same-sex encounters. Starting at three weeks age, were housed individually groups four males five weeks, after which they placed one types paired Pair consisted of: two males, socially ("mixed" pairs). Vocal behavior non-vocal behaviors recorded from these 15-minute interactions. Pairs consisting least more longer USVs, with greater proportional use USVs containing frequency jumps 50-kHz components. Individually mixed pairs levels mounting towards males. Mounting was positively correlated number duration well spectrally complex USVs. These findings demonstrate are suite influenced early-life isolation, suggest vocal following reflects reduced