Tumor microenvironment converts plasmacytoid dendritic cells into immunosuppressive/tolerogenic cells: insight into the molecular mechanisms

摘要: Human pDCs represent a rare population of circulating cells characterized by rapid and massive TLR-dependent secretion type I IFN in response to pathogenic agents or danger signals. Through their capacity bring together innate adaptive immunity secrete soluble factors controlling cancer development, these could important actors antitumor immunity. However, accumulating evidence suggests that recruited the tumor microenvironment often display nonactivated state are associated with development maintenance immunosuppression. Here, we present an overview neoplastic lesions infiltration immunosuppressive/ tolerogenic pDC. Moreover, as proper pDC against depends on critical balance between immune-activating immune-suppressing mechanisms, summarize current knowledge about molecular pathways developed tumors prevent antitumoral immune responses. A better understanding mechanisms regulating function aid new therapies. Indeed, effective vaccines therapies combine immunoactivating strategies (i.e., TLR agonists) elimination leading reprogramming thus, allowing rejection clinical setting. J. Leukoc. Biol. 93: 000–000; 2013.