Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells.
作者： Weiping Zou , Véronique Machelon , Aurore Coulomb-L'Hermin , Jozef Borvak , Françoise Nome
DOI: 10.1038/NM1201-1339
关键词: Stromal cell 、 Immunity 、 Cell biology 、 Apoptosis 、 Biology 、 Myeloid 、 Antigen 、 Chemotaxis 、 Macrophage 、 Ovarian Epithelial Tumor
摘要: Dendritic-cell (DC) trafficking and function in tumors is poorly characterized, with studies confined to myeloid DCs (DC1s). Tumors inhibit DC1 migration function, likely hindering specific immunity. The role of plasmacytoid (DC2s) tumor immunity unknown. We show here that malignant human ovarian epithelial cells express very high levels stromal-derived factor-1, which induces DC2 precursor (preDC2) chemotaxis adhesion/transmigration, upregulates preDC2 late antigen (VLA)-5, protects preDC2s from macrophage interleukin-10-induced apoptosis, all through CXC chemokine receptor-4. VLA-5 ligand vascular-cell adhesion molecule-1 mediated adhesion/transmigration. Tumor induced significant T-cell interleukin-10 unrelated differentiation or activation state, this contributed poor activation. Myeloid (preDC1s) were not detected. may weaken by attracting protecting them the harsh microenvironment, altering preDC1 distribution.
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