Screening endoscopy finds high prevalence of Helicobacter pylori and intestinal metaplasia in Korean American with limited access to health care.

作者: Yanghee Woo , Carolyn E. Behrendt , Garrick Trapp , Jae Geun Hyun , Tamas Gonda

DOI: 10.1002/JSO.24622

关键词: MedicineMetaplasiaFamily historyCancerGastritisInternal medicineFormer SmokerRisk assessmentGastroenterologyIntestinal metaplasiaHelicobacter pylori

摘要: Background Gastric cancer (GC) is the leading cause of death among Korean Americans. Prevention and early detection improved by screening. Methods Between September 2013 March 2015, ethnic Koreans age 40 or older without history symptoms GC upper endoscopy (UE) during previous 3 years were enrolled. Participants offered screening with risk assessment followed UE biopsies. Results Risk was provided to 146 participants (age 55.6 ± 8.3 years; 52.1% female; 92.5% uninsured), whom 99 (67.8%) returned for UE. Undergoing independently associated family (OR 12.33, 95% CI:1.52-100.17), being a former smoker (6.68,1.42-31.32), Hp-negative status (0.25,0.11-0.57). Among recipients, half (49.5%) had intestinal metaplasia (IM) only (n = 24), Hp (n = 12), both (n = 13). No case found. Adjusted age, IM male sex (2.89,1.12-7.42), current (2.90,0.99-8.51), unmarried (single divorced) (4.23,1.23-14.56). Conclusions High prevalence factors gastric carcinogenesis including infection exists in Americans who underwent endoscopic screening. Acceptance informed personal factors. These findings support need improve access KAs.

参考文章(29)
Chisato Hamashima, Impact of endoscopic screening on mortality reduction from gastric cancer World Journal of Gastroenterology. ,vol. 21, pp. 2460- 2466 ,(2015) , 10.3748/WJG.V21.I8.2460
Massimo Rugge, Alberto Meggio, Gianmaria Pennelli, Francesco Piscioli, Luciano Giacomelli, Giovanni De Pretis, David Y Graham, None, Gastritis staging in clinical practice: the OLGA staging system Gut. ,vol. 56, pp. 631- 636 ,(2007) , 10.1136/GUT.2006.106666
Christie E. Choi, Amnon Sonnenberg, Kevin Turner, Robert M. Genta, High Prevalence of Gastric Preneoplastic Lesions in East Asians and Hispanics in the USA Digestive Diseases and Sciences. ,vol. 60, pp. 2070- 2076 ,(2015) , 10.1007/S10620-015-3591-2
Victor Pasechnikov, Gastric cancer: Prevention, screening and early diagnosis World Journal of Gastroenterology. ,vol. 20, pp. 13842- 13862 ,(2014) , 10.3748/WJG.V20.I38.13842
Jennifer M Yeh, Chin Hur, Zachary Ward, Deborah Schrag, Sue J Goldie, Gastric adenocarcinoma screening and prevention in the era of new biomarker and endoscopic technologies: a cost-effectiveness analysis Gut. ,vol. 65, pp. 563- 574 ,(2016) , 10.1136/GUTJNL-2014-308588
Do-Youn Oh, Kui Son Choi, Hae-Rim Shin, Yung-Jue Bang, Public Awareness of Gastric Cancer Risk Factors and Disease Screening in a High Risk Region: A Population-Based Study Cancer Research and Treatment. ,vol. 41, pp. 59- 66 ,(2009) , 10.4143/CRT.2009.41.2.59
M. McCracken, M. Olsen, M. S. Chen, A. Jemal, M. Thun, V. Cokkinides, D. Deapen, E. Ward, Cancer Incidence, Mortality, and Associated Risk Factors Among Asian Americans of Chinese, Filipino, Vietnamese, Korean, and Japanese Ethnicities CA: A Cancer Journal for Clinicians. ,vol. 57, pp. 190- 205 ,(2007) , 10.3322/CANJCLIN.57.4.190
Yock Young Dan, J.B.Y. So, Khay Guan Yeoh, Endoscopic Screening for Gastric Cancer Clinical Gastroenterology and Hepatology. ,vol. 4, pp. 709- 716 ,(2006) , 10.1016/J.CGH.2006.03.025
Hee Jin Kim, Nayoung Kim, Hyun Young Kim, Hye Seung Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Do Joong Park, Hyung Ho Kim, Kyoung-Ho Lee, Young-Hoon Kim, Hee Man Kim, Dong Ho Lee, Relationship between body mass index and the risk of early gastric cancer and dysplasia regardless of Helicobacter pylori infection. Gastric Cancer. ,vol. 18, pp. 762- 773 ,(2015) , 10.1007/S10120-014-0429-0
Jin Young Park, David Forman, E. Robert Greenberg, Rolando Herrero, Helicobacter pylori Eradication in the Prevention of Gastric Cancer: Are More Trials Needed? Current Oncology Reports. ,vol. 15, pp. 517- 525 ,(2013) , 10.1007/S11912-013-0341-5