Preparation of the albumin nanoparticle system loaded with both paclitaxel and sorafenib and its evaluation in vitro and in vivo

摘要: Paclitaxel and sorafenib loaded albumin nanoparticles (PTX–SRF-BSA-NPs) were prepared studied here to avoid the toxicities from excipients in Taxol® explore effect of such combination on antitumour efficacy toxicity. PTX-BSA-NPs so used as controls. The particle size, zeta potential, encapsulation efficiency morphology evaluated. Less than 70% each drug released within 24 h. PTX SRF existed molecular or amorphous form PTX–SRF-BSA-NPs. size did not change much after 2-month storage freeze-dried 24 h suspension. treatment with PTX–SRF-BSA-NPs (7.5 mg kg−1 PTX + 7.5 mg kg−1 SRF) exhibited lower myelosuppression (15 mg kg−1 PTX) while it remained increased mice tumour models. Compared solution containing same level SRF, demonstrated significantly haemolysis effect.