1,2-DIMETHYL-3-HYDROXYPYRID-4-ONE, AN ORALLY ACTIVE CHELATOR FOR TREATMENT OF IRON OVERLOAD
作者： GeorgeJ. Kontoghiorghes , Lyndon Sheppard , MaadhA. Aldouri , A.Victor Hoffbrand
DOI: 10.1016/S0140-6736(87)90545-9
关键词: Medicine 、 Urinary system 、 Pharmacology 、 Drug 、 Chemotherapy 、 Oral administration 、 Magnesium 、 Surgery 、 Calcium 、 Excretion 、 Dosage form
摘要: Abstract Subcutaneous desferrioxamine, though effective in preventing or reducing iron overload transfusion-dependent refractory anaemia, is expensive and inconvenient. One potentially cheaper orally active alternative 1,2-dimethyl-3-hydroxypyrid-4-one (L1). This drug has been tested three multiply transfused patients with myelodysplasia. Gelatin capsules were taken at doses ranging from 0·5 g to 3·0 g. Urinary excretion increased substantially all the one was equal that achieved comparable of subcutaneous desferrioxamine. The amounts excreted related dose L1 administered load patients. urinary zinc, magnesium, calcium did not increase, well tolerated.
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