Role of a structural glycoprotein of pseudorabies in virus virulence

摘要: The virulence of deletion mutants pseudorabies virus defective in the expression glycoprotein gI, gp63, or both was tested 1-day-old chickens and young pigs. In absence a fully virulent laboratory strain, PrV(Ka), for reduced approximately fourfold. Inactivation gp63 appeared also to affect PrV(Ka) only slightly, as did inactivation gI gp63. level reduction virulence, however, considerably more marked Bartha 43/25aB4, less strain. 43/25aB4 at least 100-fold. results obtained when pigs determined were compatible with those chickens. These indicate that plays role but it does so conjunction one other viral function (a is 43/25aB4).