Characterization of the cognitive effects of combined muscarinic and nicotinic blockade.
作者： Edward D. Levin , Jed E. Rose , Susan R. McGurk , Larry L. Butcher
DOI: 10.1016/0163-1047(90)90865-4
关键词: SCH-23390 、 Mecamylamine 、 Blockade 、 Cholinergic 、 Muscarinic acetylcholine receptor 、 Pharmacology 、 Muscarinic acetylcholine receptor M4 、 Nicotinic Antagonist 、 Medicine 、 Nicotinic agonist
摘要: Choice accuracy performance in the radial-arm maze is dependent upon integrity of both nicotinic and muscarinic cholinergic receptors. Pharmacological blockade either these subtypes receptors with mecamylamine or scopolamine impairs choice maze. We have previously demonstrated that deficit caused by exacerbated at least an additive fashion coadministration antagonist, mecamylamine. In present study, it was found act together a greater than disrupting accuracy. When doses drugs which do not themselves cause significant impairments are given together, they induce pronounced impairment. Previous results shown adverse effects could be reversed dopaminergic D2 agonist LY 171555. this drug to attenuate cognitive impairment combined blockade. On other hand, D1 antagonist SCH 23390 has been reverse study Since approximates generalized underactivation, treatments like 171555, blockade, may useful treating syndromes Alzheimer's disease, characterized loss.
elsevier.com
sci-hub.se 参考文章(44)
Michael W. Decker, James L. McGaugh, Effects of concurrent manipulations of cholinergic and noradrenergic function on learning and retention in mice Brain Research. ,vol. 477, pp. 29- 37 ,(1989) , 10.1016/0006-8993(89)91391-7
InesB. Introini-Collison, JamesL. McGaugh, Modulation of memory by post-training epinephrine: involvement of cholinergic mechanisms. Psychopharmacology. ,vol. 94, pp. 379- 385 ,(1988) , 10.1007/BF00174693
J. GRENHOFF, G. ASTON-JONES, T. H. SVENSSON, Nicotinic effects on the firing pattern of midbrain dopamine neurons Acta Physiologica Scandinavica. ,vol. 128, pp. 351- 358 ,(1986) , 10.1111/J.1748-1716.1986.TB07988.X
LIISA AHTEE, SEPPO KAAKKOLA, EFFECT OF MECAMYLAMINE ON THE FATE OF DOPAMINE IN STRIATAL AND MESOLIMBIC AREAS OF RAT BRAIN; INTERACTION WITH MORPHINE AND HALOPERIDOL British Journal of Pharmacology. ,vol. 62, pp. 213- 218 ,(1978) , 10.1111/J.1476-5381.1978.TB08448.X
P.B.S. Clarke, D.W. Hommer, A. Pert, L.R. Skirboll, Electrophysiological actions of nicotine on substantia nigra single units British Journal of Pharmacology. ,vol. 85, pp. 827- 835 ,(1985) , 10.1111/J.1476-5381.1985.TB11081.X
William S. Messer, Garth J. Thomas, Wayne Hoss, Selectivity of pirenzepine in the central nervous system. II. Differential effects of pirenzepine and scopolamine on performance of a representational memory task Brain Research. ,vol. 407, pp. 37- 45 ,(1987) , 10.1016/0006-8993(87)91217-0
Paul B.S. Clarke, Agu Pert, Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons Brain Research. ,vol. 348, pp. 355- 358 ,(1985) , 10.1016/0006-8993(85)90456-1
P. Gaspar, B. Berger, C. Alvarez, A. Vigny, J. P. Henry, Catecholaminergic innervation of the septal area in man: immunocytochemical study using TH and DBH antibodies. The Journal of Comparative Neurology. ,vol. 241, pp. 12- 33 ,(1985) , 10.1002/CNE.902410103
James Watts, Robin Stevens, Clare Robinson, Effects of scopolamine on radial maze performance in rats Physiology & Behavior. ,vol. 26, pp. 845- 851 ,(1981) , 10.1016/0031-9384(81)90108-6
Claudia P. Faiman, Gabriel A. De Erausquin, Carlos M. Baratti, Mecamylamine prevents the enhancement of retention induced by lysine vasopressin in mice Behavioral and Neural Biology. ,vol. 48, pp. 434- 439 ,(1987) , 10.1016/S0163-1047(87)90996-4