F-actin cross-linking enhances the stability of force generation in disordered actomyosin networks

摘要: Myosin molecular motors and actin cross-linking proteins (ACPs) are known to mediate the generation transmission of mechanical forces within cortical F-actin cytoskeleton that drive major cellular processes such as cell division migration. However, how ACPs interact collectively over diverse timescales modulate time-dependent properties remains unclear. In this study, we present a three-dimensional agent-based computational model actomyosin network quantitatively determine effects motor activity density kinetics on accumulation maintenance tension disordered network. We found accumulate large stress quickly by behaving temporary cross-linkers although is relaxed time unless there sufficient passive stabilize Stabilization helps generate up their maximum potential, leading significant enhancement efficiency stability generation. Thus, demonstrated force-dependent ACP dissociation plays critical role for sustainment structural remodeling networks.