Long-term facilitation of ventilation in humans during NREM sleep.

摘要: The purpose of this study was to determine whether episodic hypoxic exposure would elicit long term facilitation (LTF) ventilation (V(I)) in sleeping humans. Twenty subjects gave written informed consent. Of these, six were unable maintain stable stage 2 sleep or deeper for a majority the experiment and their data excluded from analysis. On night 1 after had reached (stage deeper), breathed room air 5 minutes, followed by 3 minutes hypoxia (F(I)O2 = 8%). This sequence repeated 10 times, breathing pattern observed further 60 minutes. Subjects returned laboratory second visit, which served as sham night. Instrumentation time same on 1, but only. Airflow, tidal volume (V(T)), end O2 CO2, estimation arterial saturation (%) measured. Seven long-term (LTF), manifested significant increase V(I) that persisted up 40 following last exposure. In other seven subjects, no substantial found. We could not explain difference based body size (BMI), gender, level hypoxemia, magnitude hyperpnea during hypoxia. between two groups LTF group consisted habitual snorers, NLTF inspiratory-flow-limited experiment.