Invertase production by Aspergillus niger under solid state fermentation: Focus on physical–chemical parameters, synergistic and antagonistic effects using agro-industrial wastes

摘要: Abstract This study reports the application of experimental mixture design as a tool to evaluate effects different formulations media cultivation in invertase production by Aspergillus niger LBA 02 under solid state fermentation (SSF) using wheat bran, soybean meal, cottonseed meal and orange peel agro-industrial waste substrates. Invertase was correlated with physical–chemical parameters wastes; it shown that protein ash content well high apparent density positively influences production. Synergistic between wastes were observed during process; however, most cases, presented highest positive on After 48 h fermentation, formulation containing equal proportions an interesting synergistic effect, reaching predicted values enzyme activity higher than 100 μg−1. At 72 h reached 140 μg−1. A statistical demonstrated efficient strategy for enhancing evaluating from various sources. Furthermore, this process can also be applied studies regarding prices, availability profitability because work alternatives