[Limbic encephalitis: a probably under-recognized syndrome].

摘要: Limbic encephalitis was identified as a clinicopathological entity in 1968. Up to few years ago, 200 cases were described, most associated with lung cancer and more infrequently other tumors. The recent identification of patients this syndrome, idiopathic limbic encephalitis, who never develop have high titers antibodies voltage-gated potassium channels (VGKC) an excellent response immunosuppressive therapy, has extended the etiological spectrum suggests that syndrome may be under-recognized. disorder, which develops days or weeks, is characterized by development short-term memory loss, seizures, confusion psychiatric features. presence symptoms beyond system highly suggestive paraneoplastic origin. When suspected, following tests should performed order demonstrate: a) involvement temporal lobes (EEG brain MRI); b) inflammatory abnormalities CSF, c) onconeural anti-VGKC. Once diagnosis confirmed clinical picture MRI findings, treatment must initiated without waiting for antibody results because its negativity does not exclude diagnosis. Detection will confirm help us search underlying tumor predict possible treatment. recommended cycles methylprednisolone (1 g/day 3 5 days). Therapeutic good anti-Ma2 antibodies. On contrary, immunosuppressant usually effective anti-Hu