A Case of New Onset Psychosis in a Young Woman with Minimal Response to Risperidone, Ultimately Diagnosed with N-Methyl-D-Aspartate Receptor Encephalitis: A Review of this Under-Recognized Condition

作者: David R. Spiegel , Neil Zaki

DOI: 10.3371/CSRP.SPZA.061213

关键词:

摘要: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe, treatable and potentially reversible disorder presenting with memory deficits, psychiatric symptoms seizures. Initially described in young patients ovarian teratoma, the disease meanwhile increasingly recognized also women without tumors, men children. The presence of anti-glutamate (type NMDA) autoantibodies serum or cerebrospinal fluid specific for this novel widely under-diagnosed disorder. We present psychotic symptoms, initially treated psychiatrically, but was ultimately discovered to have anti-NMDAR encephalitis. review state respect epidemiology, phenomenology, pathogenesis, treatment.

参考文章(28)
F Graus, A Saiz, [Limbic encephalitis: a probably under-recognized syndrome]. Neurologia. ,vol. 20, pp. 24- 30 ,(2005)
Takuya Matsumoto, Kenji Matsumoto, Toshiyuki Kobayashi, Satoshi Kato, Electroconvulsive therapy can improve psychotic symptoms in anti-NMDA-receptor encephalitis Psychiatry and Clinical Neurosciences. ,vol. 66, pp. 242- 243 ,(2012) , 10.1111/J.1440-1819.2012.02324.X
Josep Dalmau, Limbic encephalitis and variants related to neuronal cell membrane autoantigens Rinshō shinkeigaku Clinical neurology. ,vol. 48, pp. 871- 874 ,(2008) , 10.5692/CLINICALNEUROL.48.871
Tareq Braik, Arthur T. Evans, Margaret Telfer, Susan McDunn, Paraneoplastic neurological syndromes: unusual presentations of cancer. A practical review. The American Journal of the Medical Sciences. ,vol. 340, pp. 301- 308 ,(2010) , 10.1097/MAJ.0B013E3181D9BB3B
Erdem T??z??n, Josep Dalmau, Limbic Encephalitis and Variants: Classification, Diagnosis and Treatment The Neurologist. ,vol. 13, pp. 261- 271 ,(2007) , 10.1097/NRL.0B013E31813E34A5
Klaus-Peter Wandinger, Sandra Saschenbrecker, Winfried Stoecker, Josep Dalmau, Anti-NMDA-receptor encephalitis: a severe, multistage, treatable disorder presenting with psychosis. Journal of Neuroimmunology. ,vol. 231, pp. 86- 91 ,(2011) , 10.1016/J.JNEUROIM.2010.09.012
F. Asztely, E. Kumlien, The diagnosis and treatment of limbic encephalitis Acta Neurologica Scandinavica. ,vol. 126, pp. 365- 375 ,(2012) , 10.1111/J.1600-0404.2012.01691.X
John E. Overall, Donald R. Gorham, The Brief Psychiatric Rating Scale Psychological Reports. ,vol. 10, pp. 799- 812 ,(1962) , 10.2466/PR0.1962.10.3.799