The relationship between obesity and neurocognitive function in Chinese patients with schizophrenia

摘要: Studies have reported that up to 60% of individuals with schizophrenia are overweight or obese. This study explored the relationship between obesity and cognitive performance in Chinese patients schizophrenia. Outpatients aged 18–50 years were recruited from 10 sites across China. Demographic clinical information was collected. A neuropsychological battery including tests attention, processing speed, learning/memory, executive functioning used assess function, these 4 individual domains transformed into a neurocognitive composite z score. In addition, height weight measured calculate body mass index (BMI). Patients categorized groups (underweight, normal weight, obese) based on BMI cutoff values for Asian populations recommended by World Health Organization. total number 896 enrolled study. Fifty-four percent participants higher significantly associated lower scores Wechsler Memory Scale-Revised (WMS-R) Visual Reproduction subscale, Adult Intelligence (WAIS-R) Digit Symbol score (p’s ≤ 0.024). Obese had than Trail Making Test B, WMS-R WAIS (p’s ≤ 0.004). Our suggests that, addition its well established risk various cardiometabolic conditions, is also decreased function Future studies should explore if loss management can improve obese who suffer