Antibiotics for treating lower urinary tract infection in children

摘要: Background Urinary tract infection (UTI) is one of the most common bacterial infections in infants and children. Lower UTI commonly presenting majority cases can be easily treated with a course antibiotic therapy no further complications. A number antimicrobials have been used to treat children lower UTIs; however it unclear what are specific benefits harms such treatments. Objectives This review aims summarise antibiotics for treating children. Search methods We searched Renal Group's Specialised Register (April 2012), CENTRAL (The Cochrane Library 2012, Issue 5), MEDLINE OVID SP (from 1966), EMBASE 1988) without language restriction. Date last search: May 2012. Selection criteria Randomised controlled trials (RCTs) quasi-RCTs which was bacteriologically proven, symptomatic, aged zero 18 years primary community healthcare settings were included. Data collection analysis Two authors independently assessed study quality extracted data. Statistical analyses performed using random effects model results expressed as risk ratios (RR) 95% confidence intervals (CI). Main results Sixteen RCTs, analysing 1,116 included. Conventional 10-day treatment significantly increased free persistent bacteriuria compared single-dose (6 studies, 228 children: RR 2.01, 95%CI 1.06 3.80). No heterogeneity observed. Persistent at end reported 24% receiving 10% who randomised therapy. There significant differences between groups symptoms, recurrence following treatment, or re-infection treatment. insufficient data analyse effect on renal parenchymal damage, compliance, development resistant organisms adverse events. Despite inclusion 16 methodological weakness small sample sizes made difficult conclude if any included regimens superior another. Authors' conclusions Although effective UTI, there answer question type duration symptomatic UTI. This found that more likely eliminate bacteria from urine than treatments. observed bacteriuria, short long-course where differed groups. adds an existing comparing same also evidence difference antibiotics.