Short-course versus conventional length antimicrobial therapy for uncomplicated lower urinary tract infections in children: A meta-analysis of 1279 patients

摘要: Abstract Objective: The objective was to compare the efficacies of single-dose, short-course (4 days or less), and standard course (5 greater) antimicrobial therapy for uncomplicated childhood cystitis. Methods: Prospective, randomized, controlled trials comparing 4 less (short courses) with 5 more (conventional therapy) were included if all subjects Results: Of 517 citations identified by literature search, 37 selected detailed review, 22 in final meta-analysis. overall difference cure rates between short conventional courses significant (6.38%; 95% CI: 1.88% 10.89%), favoring course. Similar results obtained when only studies same agents (7.92%; 2.09% 13.8%). Short-course amoxicillin inferior length (difference rate, 13%; 4% 24%); no found trimethoprim-sulfamethoxazole 6.24%; CI=–3.74% 16.2%). Conclusions: We conclude that single-dose is inadequate cystitis childhood. Three appears be as effective drug. (J Pediatr 2001;139:93-9)