The Role of Bacterial Adhesins in the Outcome of Childhood Urinary Tract Infections
作者： Candice E. Johnson
DOI: 10.1001/ARCHPEDI.1993.02160340076018
关键词: Urinary system 、 Surgery 、 Randomized controlled trial 、 Amoxicillin 、 Antibiotics 、 Vesicoureteral reflux 、 Medicine 、 Bacterial adhesin 、 Clavulanic acid 、 Amoxicillin-Potassium Clavulanate Combination 、 Internal medicine
摘要: • Objective. —To compare the efficacy of 3-day vs 10-day treatment with a combination amoxicillin and clavulanate potassium for children uncomplicated urinary tract infections to determine role host factors, including vesicoureteral reflux, bacterial virulence adhesins, in outcome. Design. —Randomized, double-blind, controlled trial. Setting. —A pediatric infectious diseases clinic at an urban medical center. Patients. —Thirty-seven infections. Interventions. —Treatment 3 days or 10 antibiotics dosage 20 mg/kg per day 5 three divided doses. Measurements Main Results. —The success rate was 82% (14/17) compared 55% (11/20) ( P =.09). Among 35 patients infected Escherichia coli, all adhesin-negative isolates were treated successfully regardless duration treatment, whereas only 14 (56%) 25 involving adhesin-positive clinically cured =.015). Two failures group reflux. Conclusions. —We conclude that is insufficient afebrile childhood both factors affect AJDC . 1993;147:1090-1093)
sci-hub.se 参考文章(15)
P de Man, B Cedergren, S Enerbäck, A C Larsson, H Leffler, A L Lundell, B Nilsson, C Svanborg-Edén, Receptor-specific agglutination tests for detection of bacteria that bind globoseries glycolipids. Journal of Clinical Microbiology. ,vol. 25, pp. 401- 406 ,(1987) , 10.1128/JCM.25.2.401-406.1987
M Archambaud, P Courcoux, V Ouin, G Chabanon, A Labigne-Roussel, Phenotypic and genotypic assays for the detection and identification of adhesins from pyelonephritic Escherichia coli Annales De L'institut Pasteur. Microbiologie. ,vol. 139, pp. 557- 573 ,(1988) , 10.1016/0769-2609(88)90155-X
J R Johnson, Virulence factors in Escherichia coli urinary tract infection. Clinical Microbiology Reviews. ,vol. 4, pp. 80- 128 ,(1991) , 10.1128/CMR.4.1.80
J M Smellie, P G Ransley, I C Normand, N Prescod, D Edwards, Development of new renal scars: a collaborative study. BMJ. ,vol. 290, pp. 1957- 1960 ,(1985) , 10.1136/BMJ.290.6486.1957
KAREN J. CARLSON, Management of Acute Dysuria Annals of Internal Medicine. ,vol. 102, pp. 244- 249 ,(1985) , 10.7326/0003-4819-102-2-244
GILBERT MADRIGAL, CARLA M. ODIO, EDGAR MOHS, J GUEVARA, GEORGE H MCCRACKEN, Single dose antibiotic therapy is not as effective as conventional regimens for management of acute urinary tract infections in children Pediatric Infectious Disease Journal. ,vol. 7, pp. 316- 319 ,(1988) , 10.1097/00006454-198805000-00004
John T. Philbrick, Single-Dose Antibiotic Treatment for Uncomplicated Urinary Tract Infections Archives of Internal Medicine. ,vol. 145, pp. 1672- 1678 ,(1985) , 10.1001/ARCHINTE.1985.00360090144022
Eugene D. Shapiro, Ellen R. Wald, Single-dose amoxicillin treatment of urinary tract infections The Journal of Pediatrics. ,vol. 99, pp. 989- 992 ,(1981) , 10.1016/S0022-3476(81)80039-X
S Petersen, L Brendstrup, A Hansen, V Hvorslev, V Brændholdt-Jensen, B Pagh, KE Petersen, A Pærregaard, G Schou, C Vrang, O Daubjerg, Hjelt K, OH Nielsen, Reinholdt J, H Sardemann, B Stagegård, T Sørensen, K Tobiassen, I Winsløv, Short-term treatment of acute urinary tract infection in girls Scandinavian Journal of Infectious Diseases. ,vol. 23, pp. 213- 220 ,(1991) , 10.3109/00365549109023403
S. R. Norrby, Short-Term Treatment of Uncomplicated Lower Urinary Tract Infections in Women Clinical Infectious Diseases. ,vol. 12, pp. 458- 467 ,(1990) , 10.1093/CLINIDS/12.3.458