Mutagenesis Associated with Repair of DNA Double-Strand Breaks Under Stress

摘要: Evolutionary theory predicted that mutations occur randomly both in time and genomic space. This expectation has been revised by the discoveries of stress-induced mutation mechanisms, which activate mutagenesis pathways under control stress responses. Stress-induced mechanisms produce preferentially when cells or organisms are maladapted to their environment, i.e., they stressed, potentially accelerating evolution. We review stress-­induced associated with repair double-strand breaks Escherichia coli. In this mechanism, process DNA break homologous recombination is high-fidelity unstressed cells, but switched a mutagenic mode using error-prone polymerase DinB, other polymerases, RpoS general response. The switch occurs during starvation if upregulated artificially presumably many different stresses Recent work shows mechanism accounts for most spontaneous base-substitution frameshift E. coli, acts not only plasmid also chromosomes plasmid-free illustrates generality circumstances, resolves some old tensions field. studied laboratory likely provide superior models underlying pathogen-host adaptation, antibiotic resistance, cancer progression resistance all problems evolution driven mutations.