Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis

摘要: A wound is a type of injury that damages living tissues. In this review, we will be referring mainly to healing responses in the organs including skin and lungs. Fibrosis process dysregulated extracellular matrix (ECM) production leads dense functionally abnormal connective tissue compartment (dermis). tissues such as skin, repair dermis after wounding requires not only fibroblasts produce ECM molecules, but also overlying epithelial layer (keratinocytes), endothelial cells, smooth muscle cells blood vessel white neutrophils macrophages, which together orchestrate cytokine-mediated signaling paracrine interactions are required regulate proper extent timing process. This review focus on importance molecules microenvironment, primarily proteoglycans glycosaminoglycan hyaluronan, their roles healing. First, briefly summarize physiological, cellular, biochemical elements healing, cytokine cross-talk between cell types. Second, discuss role hyaluronan regulating these processes. Finally, approaches utilize concepts potential therapies for fibrosis discussed.