Local drug delivery

摘要: An implant having a coating comprising polymer matrix is swollen in pharmaceutical solution whereby pharmaceutically active compound imbibed into the matrix. When product implanted, release of from takes place. The preferably formed ethylenically unsaturated monomers including zwitterionic monomer, most 2-methacryloyloxyethyl-2'-trimethylammoniumethylphosphate inner salt. which may further include surface binding monomers, such as hydrophobic group containing and crosslinkable content be used to control swellability. Preferably stent on exterior wall thicker than interior surface. Release drug controlled by selection comonomers. suitably for use cardiovascular system.