Hsa-miR-196a2 functional SNP is associated with the risk of ESCC in individuals under 60 years old.
作者： Na Wang , Yan Li , Rong-Miao Zhou , Gui-Ying Wang , Chun-Mei Wang
DOI: 10.3109/1354750X.2013.866164
关键词: Genotype 、 Cell 、 Molecular biology 、 RNA 、 microRNA 、 SNP 、 Polymerase chain reaction 、 Gene 、 Biology 、 Single-nucleotide polymorphism
摘要: AbstractBackground and aim: The miR-196a2 gene contains a C/T polymorphism (rs11614913). Its presence could change the conformation of secondary structure RNA, directly affect binding to target mRNAs miRNA maturation process. Both which eventually alter protein expression contributed cancer susceptibility. This study assessed whether rs11614913 single nucleotide (SNP) an individual’s susceptibility esophageal squamous cell carcinomas (ESCC).Methods: SNP was genotyped by polymerase chain reaction ligase detection (PCR-LDR) in 597 ESCC patients control subjects.Results: Overall, there were no significant differences frequency miRNA-196a2 genotype between cases controls (χ2 = 1.395, p = 0.498). TT genotype, CT CT/TT combined (dominant model) did not modify risk as compared with CC genotype. Comparisons to...
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