Conformation—function relationships for peptide bioregulators as revealed by theoretical conformation analysis
作者： G.V. Nikiforovich
DOI: 10.1016/0166-1280(86)80005-7
关键词: Peptide 、 Steric effects 、 Stereochemistry 、 Oligopeptide 、 Function (biology) 、 Chemistry 、 Affinities
摘要: Abstract This paper reports some current developments in the study of conformation—function relationships biologically active oligopeptides using theoretical conformational analysis atom—atom approximation. The principles employed search for peptide conformations, which involves comparison calculated sets low-energy structures natural and its analogues with various affinities towards specific receptors, are outlined illustrated by examples peptides. synthesis cyclic linear peptides order to fix their conformations is proposed as a prospective approach design effective bioregulators. Energy calculations cyclo-analogues steric putative given.
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