Conformational features responsible for binding of cyclic analogues of enkephalin to opioid receptors. I. Low-energy peptide backbone conformers of analogues containing Phe4.

摘要: Low-energy peptide backbone conformers were found by means of energy calculation for several cyclic analogues enkephalin in an attempt to assess models receptor-bound conformations opioid receptors the mu- and delta-types. They included [D-Cys2, L-Cys5]- D-Cys5]-enkephalinamides showing moderate preference mu-receptors, delta-selective compounds [D-Pen2, L-Pen5] D-Pen5]-enkephalins Tyr-D-Lys-Gly-Phe- analogue possessing very high affinity mu-type. The low-energy obtained these good agreement with results calculations other authors experimental evidence. All contain a Phe residue position 4 chain which facilitates eventual search geometrical similarity between different question.