Inflammatory cytokine IL6 cooperates with CUDR to aggravate hepatocyte-like stem cells malignant transformation through NF-κB signaling

摘要: Inflammatory cytokines and lncRNAs are closely associated with tumorigenesis. Herein, we reveal inflammatory IL6 cooperates long noncoding RNA CUDR to trigger the malignant transformation of human embryonic stem cells-derived hepatocyte-like cells. Mechanistically, cause MELLT3 interact SUV39h1 mRNA3′UTR promote expression. Moreover, excessive also increases tri-methylation histone H3 on nineth lysine (H3K9me3). Intriguingly, under conditions, H3K9me3 promotes expression phosphorylation NF-κB, in turn, phorsphorylated NF-κB Stat3. Furthermore, that phosphorylated Stat3 loads onto promoter region miRs lncRNAs. Ultimately, abnormal increased telomerase activity, telomere length microsatellite instability (MSI), leading