Association of the anti-angiogenic factor secreted protein and rich in cysteine (SPARC) with vascular complications among Chinese type 2 diabetic patients in Singapore
作者： Mei Chung Moh , Chee Fang Sum , Subramaniam Tavintharan , Sharon Li Ting Pek , Lee Ying Yeoh
DOI: 10.1016/J.JDIACOMP.2016.03.029
关键词: Cohort 、 Medicine 、 Diabetes mellitus 、 Type 2 diabetes 、 Pathophysiology 、 Endocrinology 、 Immunology 、 Matrix metalloproteinase 、 Osteopontin 、 Cell adhesion molecule 、 Internal medicine 、 Adiponectin
摘要: Abstract Aims This study evaluated the association of anti-angiogenic SPARC with known angiogenesis-associated factors and diabetes-related micro- macro-vascular complications in a Singapore Chinese cohort type 2 diabetes (T2DM). Methods Plasma was measured by immunoassay 438 T2DM adults (mean age:58±11years). Results Higher levels subjects stratified tertiles displayed decreased pro-angiogenic adiponectin, osteopontin, vascular cell adhesion molecule (VCAM)-1 matrix metalloproteinase (MMP)-2 concentrations (all p Conclusions The may be associated pathophysiology macrovascular complications.
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