Hepatitis B Virus DNA in Patients with Chronic Liver Disease and Negative Tests for Hepatitis B Surface Antigen
作者： Christian Bréchot , Françoise Degos , Claire Lugassy , Valérie Thiers , Serge Zafrani
DOI: 10.1056/NEJM198501313120503
关键词: Virus 、 HBsAg 、 Virology 、 Hepatobiliary disease 、 Hepatitis B virus 、 Hepatocellular carcinoma 、 Chronic liver disease 、 Hepatitis B virus DNA polymerase 、 Hepatitis 、 Medicine 、 Immunology 、 General Medicine
摘要: Abstract We assessed the presence of hepatitis B virus (HBV) DNA in liver or serum samples from 134 patients with surface antigen (HBsAg)-negative chronic disease, including 20 hepatocellular carcinoma. HBV sequences were detected 52 88 (59 per cent), 17 Presumably "replicative forms" only 5 samples, 3 which no serologic marker for HBV. In most patterns consistent a closely related virus. Of 105 tested, identified 10 (9.5 6 had marker. Moreover, HBsAg-associated determinants who positive and none 14 negative. This study demonstrates high frequency HBsAg-negative DNA–positive viral infectio...
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