The systematic annotation of the three main GPCR families in Reactome

摘要: Reactome is an open-source, freely available database of human biological pathways and processes. A major goal our work to provide integrated view cellular signalling processes that spans from ligand–receptor interactions molecular readouts at the level metabolic transcriptional events. To this end, we have built first catalogue all G protein-coupled receptors (GPCRs) known bind endogenous or natural ligands. The UniProt has records for 797 proteins classified as GPCRs sorted into families A/1, B/2 C/3 on basis amino accid sequence. these added details IUPHAR own manual curation relevant literature create reactions in which 563 ligands also interact with specific G-proteins initiate cascades. We believe remaining 234 are true orphans. GPCR pathway can be viewed a detailed interactive diagram exported many forms. It provides template orthology-based inference diverse model organism species, overlaid protein–protein interaction gene expression datasets facilitate overrepresentation studies other forms analysis. Database URL: http://www.reactome.org