作者: John P. Overington , Bissan Al-Lazikani , Andrew L. Hopkins
DOI: 10.1038/NRD2199
关键词: Molecular targets 、 Drug approval 、 Computational biology 、 Drug 、 Medicine 、 Polypharmacology 、 Pharmacology 、 Target protein
摘要: … location: 60% of drug targets are located at the cell surface, compared with only ∼22% of all proteins in the human genome. Despite this strong pattern of membrane association, there …