Comparative study of quantitative ultrasonography and dual-energy X-ray absorptiometry for evaluating renal osteodystrophy in children with chronic kidney disease
作者： Athanasios Christoforidis , Nikoleta Printza , Chrysa Gkogka , Ekaterini Siomou , Anna Challa
DOI: 10.1007/S00774-010-0220-1
关键词: Kidney disease 、 Bone mineral 、 Bone remodeling 、 Renal osteodystrophy 、 Osteocalcin 、 Medicine 、 Tibia 、 Dual-energy X-ray absorptiometry 、 Internal medicine 、 Osteoprotegerin 、 Endocrinology 、 Urology
摘要: Our aim was to assess bone parameters in children with chronic kidney disease (CKD) both dual-energy X-ray absorptiometry (DXA) and quantitative ultrasonography (QUS) additionally biochemical markers of turnover. Twenty (12 boys 8 girls) CKD a mean decimal age 9.47 ± 4.44 years were included the study where anthropometric (height weight), pubertal status, mineral density (BMD) at lumbar spine, speed sound (SOS) measured by QUS radius tibia, metabolism measured. Six patients (30%) had tibial SOS Z score <−1, 52.7% radial whereas only 16.67% BMD <−1. Patients significantly increased levels serum intact parathormone (p < 0.001), alkaline phosphatase (BAP) 0.001) N-terminal-mid fragment (aminoacids 1-43) osteocalcin compared controls, osteoprotegerin decreased controls = 0.001). correlated BAP (r −0.586, p 0.013 r −0.709, 0.001, respectively, for tibia). In conclusion no association between DXA measurements documented our study, better indices ROD.
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