The Controversy Around Sirtuins and Their Functions in Aging
作者： Yu Sun , Weiwei Dang
DOI: 10.1016/B978-0-12-801816-3.00017-0
关键词: Drug development 、 Calorie restriction 、 Gerontology 、 Sirtuin 、 Biology
摘要: Sirtuins are a class of evolutionarily conserved protein deacetylases and ADP-ribosyltransferases. Many them have been closely associated with aging mechanisms potential antiaging interventions based on research in this area investigated the past decade. However, accompanying their rising fame, debates functional roles sirtuins regulation involvement age-associated diseases, such as cancer, heated up, not only scientific community, but also among general public. In chapter, we will discuss controversies that received most attentions recent years, hoping to shed light applications future sirtuin-based drug development.
sci-hub.se 参考文章(194)
Nan Jiang, Guyu Du, Ethan Tobias, Jason G. Wood, Rachel Whitaker, Nicola Neretti, Stephen L. Helfand, Dietary and genetic effects on age-related loss of gene silencing reveal epigenetic plasticity of chromatin repression during aging. Aging (Albany NY). ,vol. 5, pp. 813- 824 ,(2013) , 10.18632/AGING.100614
Yong-Ru Chen, Shi-Rong Fang, Yu-Cai Fu, Xiao-Hui Zhou, Ming-Yan Xu, Wen-Can Xu, Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats. Biochemistry and Cell Biology. ,vol. 88, pp. 715- 722 ,(2010) , 10.1139/O10-010
Hualing Sun, Yanru Wu, Dongjie Fu, Yinchen Liu, Cui Huang, SIRT6 regulates osteogenic differentiation of rat bone marrow mesenchymal stem cells partially via suppressing the nuclear factor-κB signaling pathway. Stem Cells. ,vol. 32, pp. 1943- 1955 ,(2014) , 10.1002/STEM.1671
Li-Li Luo, Jin-Jie Xu, Xing-Mei Zhang, Xiao-Chun Chen, Li Li, Yan-Fang Xiang, Xuan-Hao Lin, Yu-Cai Fu, The effects of caloric restriction and a high-fat diet on ovarian lifespan and the expression of SIRT1 and SIRT6 proteins in rats Aging Clinical and Experimental Research. ,vol. 24, pp. 125- 133 ,(2012) , 10.3275/7660
L Guarente, Diverse and dynamic functions of the Sir silencing complex. Nature Genetics. ,vol. 23, pp. 281- 285 ,(1999) , 10.1038/15458
Stefan U. Åström, Jasper Rine, Thomas W. Cline, The Drosophila melanogaster sir2+ gene is nonessential and has only minor effects on position-effect variegation. Genetics. ,vol. 163, pp. 931- 937 ,(2003) , 10.1093/GENETICS/163.3.931
Louis R Lapierre, Caroline Kumsta, Marco Sandri, Andrea Ballabio, Malene Hansen, Transcriptional and epigenetic regulation of autophagy in aging Autophagy. ,vol. 11, pp. 867- 880 ,(2015) , 10.1080/15548627.2015.1034410
David A Sinclair, Leonard Guarente, Extrachromosomal rDNA circles--a cause of aging in yeast. Cell. ,vol. 91, pp. 1033- 1042 ,(1997) , 10.1016/S0092-8674(00)80493-6
Yuxun Zhang, Sivakama S. Bharathi, Matthew J. Rardin, Radha Uppala, Eric Verdin, Bradford W. Gibson, Eric S. Goetzman, SIRT3 and SIRT5 Regulate the Enzyme Activity and Cardiolipin Binding of Very Long-Chain Acyl-CoA Dehydrogenase PLOS ONE. ,vol. 10, pp. e0122297- ,(2015) , 10.1371/JOURNAL.PONE.0122297
Lorena Aguilar-Arnal, Sayako Katada, Ricardo Orozco-Solis, Paolo Sassone-Corsi, NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1 Nature Structural & Molecular Biology. ,vol. 22, pp. 312- 318 ,(2015) , 10.1038/NSMB.2990